Article
D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting.
Circulation - 1 Jul 1997
Amant C, Bauters C, Bodart J C, Lablanche J M, Grollier G, Danchin N, Hamon M, Richard F, Helbecque N, McFadden E P, Amouyel P, Bertrand M E
Abstract excerpt
BACKGROUND: Although intracoronary stent implantation significantly reduces restenosis compared with balloon angioplasty, a minority of patients still develop restenosis predominantly due to neointimal hyperplasia. Experimental studies suggest that the renin-angiotensin system is involved in neointimal hyperplasia after arterial injury. In humans, the plasma and cellular levels of ACE are associated with an I/D...
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