Article
Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro
1 Aug 1997
Abstract excerpt
The extensive proliferation that B lymphocytes undergo in germinal centers could compromise generation of long term B cell memory if there occurs shortening of the telomeres of germinal center B cells with cell division. Telomere length, which is thought to act as a "mitotic clock" for somatic cells that dictates cellular senescence, can be preserved by the enzyme telomerase. Human tonsil germinal center B cells...
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