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Article

Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2.

Journal of cellular physiology - 1 Jul 1997

Mangasarian K, Li Y, Mansukhani A, Basilico C

Abstract excerpt

FGF signaling is clearly important for proper bone development, and several autosomally dominant forms of genetic bone disorders have been mapped to FGF receptors 1, 2, and 3. We have studied the biological effects of the most commonly mutated cysteine residue in FGFR-2 which is detected in individuals with Crouzon syndrome, an autosomally dominant trait which causes premature fusion of the skull bones...

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Identifiers

PMID: 9207932
DOI: 10.1002/(SICI)1097-4652(199707)172:1<117::AID-JCP13>3.0.CO;2-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2.PMID 9207932Read ↗

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Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.Semantic proximity Read ↗

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome.Semantic proximity Read ↗

Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.Semantic proximity Read ↗

Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome.Semantic proximity Read ↗

Further analysis of the Crouzon mouse: effects of the FGFR2(C342Y) mutation are cranial bone-dependent.Semantic proximity Read ↗

The C342R mutation in FGFR2 causes Crouzon syndrome with elbow deformity.Semantic proximity Read ↗

A novel fibroblast growth factor receptor 2 (FGFR2) mutation associated with a mild Crouzon syndrome.Semantic proximity Read ↗

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Crouzon syndrome: mutations in two spliceoforms of FGFR2 and a common point mutation shared with Jackson-Weiss syndrome.Semantic proximity Read ↗

FGFR2 mutations and associated clinical observations in two Chinese patients with Crouzon syndrome.Semantic proximity Read ↗

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