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Article

Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2.

Journal of cellular physiology - 1 Jul 1997

Mangasarian K, Li Y, Mansukhani A, Basilico C

Abstract excerpt

FGF signaling is clearly important for proper bone development, and several autosomally dominant forms of genetic bone disorders have been mapped to FGF receptors 1, 2, and 3. We have studied the biological effects of the most commonly mutated cysteine residue in FGFR-2 which is detected in indiv...

Topics

3T3 Cells
Animals
COS Cells
Cell Differentiation
Craniosynostoses
Dimerization
Disulfides
Genes, Dominant
Glycosylation
Ligands
Mice
Mutation
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Processing, Post-Translational

Receptor Protein-Tyrosine Kinases

Receptor, Fibroblast Growth Factor, Type 2

Receptors, Fibroblast Growth Factor

Source

Identifiers

PMID: 9207932
DOI: 10.1002/(SICI)1097-4652(199707)172:1<117::AID-JCP13>3.0.CO;2-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9207932-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2.PMID 9207932Read ↗

The Fgfr2 W290R mouse model of Crouzon syndrome.Semantic proximity Read ↗

A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis.Semantic proximity Read ↗

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.Semantic proximity Read ↗

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome.Semantic proximity Read ↗

Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.Semantic proximity Read ↗

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Crouzon syndrome: mutations in two spliceoforms of FGFR2 and a common point mutation shared with Jackson-Weiss syndrome.Semantic proximity Read ↗

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