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Article

Rarity of dominant-negative mutations of the G-CSF receptor in patients with blast crisis of chronic myeloid leukemia or de novo acute leukemia.

Leukemia - 1 Jul 1997

Carapeti M, Soede-Bobok A, Hochhaus A, Sill H, Touw I P, Goldman J M, Cross N C

Abstract excerpt

It is likely that leukemia results, at least in part, from mutations that lead to a block in the normal process of differentiation. A defined region of the cytoplasmic domain of the granulocyte colony-stimulating factor receptor (G-CSF-R) transmits signals for maturation or differentiation of myeloid progenitor cells. Mutations in this region have been found in some patients with severe congenital neutropenia...

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 9204982
DOI: 10.1038/sj.leu.2400697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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