Article
An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis.
Cell - 13 Jun 1997
Lazazzera B A, Solomon J M, Grossman A D
Abstract excerpt
Competence development and sporulation in B. subtilis are partly controlled by peptides that accumulate in culture medium as cells grow to high density. We constructed two genes that encode mature forms of two different signaling molecules, the PhrA peptide that stimulates sporulation, and CSF, the competence- and sporulation-stimulating factor. Both pentapeptides are normally produced by secretion and processing...
Topics
- ATP-Binding Cassette Transporters
- Alanine
- Bacillus subtilis
- Bacterial Proteins
- Base Sequence
- Cell Communication
- Cell Count
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Genotype
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutagenesis
- Peptide Synthases
- Phenotype
- Sigma Factor
- Spores, Bacterial