Perspectives series: cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis.

Abstract excerpt

Lesions of atherosclerosis are only found in the intima, and the smooth muscle cells (SMC) 1 comprising these lesions are clonal. These two simple facts imply that formation of the intima, presumably by migration of cells from the media, is a key event in the early stages of atherosclerosis. There is also a lot of interest (1), although less data, in the possibility that smooth muscle migration and proliferation...

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