Article
Vascular smooth muscle cells in atherosclerosis.
Nature reviews. Cardiology - 1 Dec 2019
Basatemur Gemma L, Jørgensen Helle F, Clarke Murray C H, Bennett Martin R, Mallat Ziad
Abstract excerpt
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and hence stabilize plaques. However, lineage-tracing studies have...
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