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Article

Somatic Instability of the Myotonic Dystrophy (CTG)n Repeat during Human Fetal Development

1 Jun 1997

Abstract excerpt

Myotonic dystrophy is characterised by the striking level of somatic heterogeneity seen between and within tissues of the same patient, which probably accounts for a significant proportion of the pleiotropy associated with this disorder. The congenital form of the disease is associated with the largest (CTG)n repeat expansions. We have investigated the timing of instability of myotonic dystrophy (CTG)n repeats in...

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Identifiers

PMID: 9175733
DOI: 10.1093/hmg/6.6.877

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Somatic Instability of the Myotonic Dystrophy (CTG)n Repeat during Human Fetal DevelopmentPMID 9175733Read ↗

Progression of somatic CTG repeat length heterogeneity in the blood cells of myotonic dystrophy patients.Semantic proximity Read ↗

Somatic instability of CTG repeat in myotonic dystrophy.Semantic proximity Read ↗

Size of the unstable CTG repeat sequence in relation to phenotype and parental transmission in myotonic dystrophy.Semantic proximity Read ↗

Somatic instability of the expanded CTG triplet repeat in myotonic dystrophy type 1 is a heritable quantitative trait and modifier of disease severity.Semantic proximity Read ↗

Instability in the transmission of the myotonic dystrophy CTG repeat in human oocytes and preimplantation embryos.Semantic proximity Read ↗

CTG repeat instability in a human embryonic stem cell line carrying the myotonic dystrophy type 1 mutation.Semantic proximity Read ↗

De novo repeat interruptions are associated with reduced somatic instability and mild or absent clinical features in myotonic dystrophy type 1.Semantic proximity Read ↗

Relationship Between Parental Trinucleotide GCT Repeat Length and Severity of Myotonic Dystrophy in OffspringSemantic proximity Read ↗

Myotonic dystrophy: size- and sex-dependent dynamics of CTG meiotic instability, and somatic mosaicism.Semantic proximity Read ↗

Unstable DNA sequence in myotonic dystrophy.Semantic proximity Read ↗

Instability of normal (CTG)n alleles in the DM kinase gene.Semantic proximity Read ↗

Unstable DNA may be responsible for the incomplete penetrance of the myotonic dystrophy phenotype.Semantic proximity Read ↗

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