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Article

Relationship Between Parental Trinucleotide GCT Repeat Length and Severity of Myotonic Dystrophy in Offspring

21 Apr 1993

Abstract excerpt

OBJECTIVE: To assess the relationship between the GCT repeat number in the myotonic dystrophy gene and the clinical phenotype and examine its predictive utility in prenatal testing. DESIGN: DNA from patients was examined for the length of the myotonic dystrophy GCT repeat region, using both Southern blot analysis and polymerase chain reaction. The results were compared with the clinical onset of disease, as well...

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PMID: 8464127
DOI: 10.1001/jama.1993.03500150072029

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