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Article

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.

Journal of microbiology (Seoul, Korea) - 1 Apr 2015

Xu Lijia, Grandi Nicole, Del Vecchio Claudia, Mandas Daniela, Corona Angela, Piano Dario, Esposito Francesca, Parolin Cristina, Tramontano Enzo

Abstract excerpt

HIV-1 reverse transcriptase (RT) is still an extremely attractive pharmaceutical target for the identification of new inhibitors possibly active on drug resistant strains. Medicinal plants are a rich source of chemical diversity and can be used to identify novel scaffolds to be further developed by chemical modifications. We investigated the ability of the main lignans from Schisandra chinensis (Turcz.) Baill....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25740376
DOI: 10.1007/s12275-015-4652-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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