The first detection of complete androgen insensitivity with no mutation in the coding sequence of the androgen receptor gene.

doi:10.2741/a103

Back to search

Article

The first detection of complete androgen insensitivity with no mutation in the coding sequence of the androgen receptor gene.

Frontiers in bioscience : a journal and virtual library - 1 Jul 1996

Lee H J, Mowszowicz I, Chang C

Abstract excerpt

We have analyzed the entire nucleotide sequences of complementary DNAs of the androgen receptor gene in two siblings (patients 8044 and 8047) with complete androgen insensitivity. Plasma testosterone was in the normal male range, however, androgen binding capacity was undetectable as measured in...

Topics

Adolescent
Androgen-Insensitivity Syndrome
Blotting, Northern
Cells, Cultured
DNA Mutational Analysis
DNA, Complementary
Humans
Karyotyping
Male
Mutation
RNA, Messenger
Receptors, Androgen
Siblings

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.