Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene.

doi:10.1111/j.1399-0004.1996.tb02738.x

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Article

Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene.

Clinical genetics - 1 Dec 1996

Besnard-Guérin C, Winqvist R, Newsham I, Cavenee W K

Abstract excerpt

We examined 63 unrelated individuals from the United States for the Apa-LI polymorphism in intron 5 of the WT1 gene. Allele frequencies of 0.13 and 0.87 for the A and B alleles, respectively, and a heterozygosity index of 24% contrast sharply with previous data obtained in the Japanese population where allele frequencies of 0.55 and 0.45 for the A and B alleles and a heterozygosity index of 59% were reported....

Topics

Alleles
DNA-Binding Proteins
Epistasis, Genetic
Gene Frequency
Genes, Wilms Tumor
Genetic Variation
Heterozygote
Humans
Incidence
Introns
Japan
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Sequence Deletion

Transcription Factors

United States

WT1 Proteins

Wilms Tumor

Source

Open in PubMed

Identifiers

PMID: 9147899
DOI: 10.1111/j.1399-0004.1996.tb02738.x

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