Article
Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA.
Antimicrobial agents and chemotherapy - 1 May 1997
Ross J I, Eady E A, Cove J H, Jones C E, Ratyal A H, Miller Y W, Vyakrnam S, Cunliffe W J
Abstract excerpt
The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible strain. In 13 isolates and the 4 laboratory mutants, cross-resistance to macrolides, lincosamides,...
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