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Article

Long-term administration of oral macrolides for acne treatment increases macrolide-resistant Propionibacterium acnes.

The Journal of dermatology - 1 Mar 2018

Nakase Keisuke, Okamoto Yuhei, Aoki Sae, Noguchi Norihisa

Abstract excerpt

Macrolide-resistant Propionibacterium acnes are frequently isolated from patients with acne vulgaris, and the most resistant isolates (>90% resistance) have the 23S rRNA mutation. An increase in resistant P. acnes with this mutation is thought to be caused by the inappropriate use of antimicrobials. Therefore, we studied the mutation frequency of macrolide resistance in P. acnes in vitro. When P. acnes mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29235673
DOI: 10.1111/1346-8138.14178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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