Article
Mapping undetected mutations within a gene-evidence for two preferential regions in the DMD gene.
Human heredity - 1 Jan 2000
Müller-Myhsok B, Heiland H J, Müller C R, Meng G, Grimm T, Ott J
Abstract excerpt
A maximum-likelihood method is developed to estimate the frequency distribution of undetected mutations (presumably point mutations, small deletions, insertions) along a gene, where the gene extends over a long stretch of DNA. In each family, the point of the mutation is potentially at a different location within the gene. In this sense, there is genetic heterogeneity among families and the method estimates the...
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