Article
Impact of migration and fitness on the stability of lethal t-haplotype polymorphism in Mus musculus: a computer study.
Genetics - 1 Apr 1997
Durand D, Ardlie K, Buttel L, Levin S A, Silver L M
Abstract excerpt
The t-haplotype is a chromosomal region in Mus musculus characterized by meiotic drive such that heterozygous males transmit t-bearing chromosomes to roughly 90% of their offspring. Most naturally occurring t-haplotypes express a recessive embryonic lethality, preventing fixation of the t-haplotype. Surprisingly, the t-haplotype occurs in nature as a persistent, low-frequency polymorphism. Early modeling studies...
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