Induction of hypoglycaemia in Japanese encephalitis virus infection: the role of T lymphocytes.

doi:10.1111/j.1365-2249.1997.281-ce1173.x

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Induction of hypoglycaemia in Japanese encephalitis virus infection: the role of T lymphocytes.

Clinical and experimental immunology - 1 Feb 1997

Khanna N, Mathur A, Bharadwaj M, Chaturvedi U C

Abstract excerpt

We report here development of hypoglycaemia in the convalescent phase of Japanese encephalitis virus (JEV) infection in mice by the induction of antigen-specific Ly1- 2+ T cells in the spleen which mediate hypoglycaemia through the generation of soluble T cell hypoglycaemic factor (TCHF). The TCHF acted in a dose-dependent manner and was found to be trypsin-sensitive and thermolabile. It was purified on...

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