Article
UKPDS 21: low prevalence of the mitochondrial transfer RNA gene (tRNA(Leu(UUR))) mutation at position 3243bp in UK Caucasian type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association - 1 Jan 1997
Saker P J, Hattersley A T, Barrow B, Hammersley M S, Horton V, Gillmer M D, Turner R C
Abstract excerpt
Some patients with Type 2 (non-insulin-dependent) diabetes mellitus possess a mitochondrial mutation in the tRNA(Leu(UUR)) gene at position 3243 bp. These subjects show a maternal mode of inheritance and often have hearing defects. In French and Japanese populations, this mutation may be present in 1-3% of subjects with a family history of diabetes. We assessed the prevalence of this mutation in newly diagnosed...
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