Article
Polymorphism of the apolipoprotein E gene and early carotid atherosclerosis defined by ultrasonography in asymptomatic adults.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 1997
Cattin L, Fisicaro M, Tonizzo M, Valenti M, Danek G M, Fonda M, Da Col P G, Casagrande S, Pincetri E, Bovenzi M, Baralle F
Abstract excerpt
Clinical and autoptical studies have suggested a predisposing role of the allele E4 of apolipoprotein E (apoE) in the development of atherosclerosis and cardiovascular disease. To investigate the possible contribution of apoE allele polymorphism to the carotid intima-media thickness (IMT) as assessed by ultrasound, we studied 260 asymptomatic nondiabetic subjects (121 men, 139 women; mean +/- SD age, 53 +/- 7...
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