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Article

Evidence for the Requirement of Autocrine Growth Factors for Development of Mouse Preimplantation Embryos in Vitro1

1 Jan 1997

Abstract excerpt

The mitotic stimuli in the early mammalian embryo have not been unequivocally identified. One hypothesis is that the embryo releases autocrine growth factors (GFs) that have a role in such growth. To determine whether such putative GFs were limited by dilution, and hence secreted, development was observed at various embryo concentrations in culture. Embryos were collected at the zygote or 2-cell stage. Zygotes...

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PMID: 9002654
DOI: 10.1095/biolreprod56.1.229

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