Article
Prevalence of factor V Leiden in children with thrombo-embolism.
European journal of pediatrics - 1 Dec 1996
Aschka I, Aumann V, Bergmann F, Budde U, Eberl W, Eckhof-Donovan S, Krey S, Nowak-Göttl U, Schobess R, Sutor A H, Wendisch J, Schneppenheim R
Abstract excerpt
UNLABELLED: Hereditary resistance to the anticoagulatory action of activated protein C (APC resistance, APCR) was identified as a possible new thrombophilic factor in a high percentage (17%-60%) of young adults with thrombotic events. A single missense mutation (R506Q) due to a G/A transition (G1...
Topics
- Adolescent
- Child
- Child, Preschool
- Factor V
- Humans
- Infant
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prevalence
- Protein C Deficiency
- Risk Factors
- Thromboembolism
