Article
Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators.
Molecular carcinogenesis - 1 Nov 1996
Fuchs-Young R, Howe S, Hale L, Miles R, Walker C
Abstract excerpt
Uterine leiomyoma is the most frequent gynecologic neoplasm in women. By using a panel of cell lines derived from spontaneous Eker rat leiomyomas, we examined the estrogen-responsive phenotype of these tumor cells. Leiomyoma-derived ELT cell lines proliferated in response to estrogen, and estrogen-induced cell proliferation could be inhibited by the estrogen antagonist ICI 182780 and the selective...
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