Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model.

Fertility and sterility - 1 Jan 2010

Hassan Memy H, Salama Salama A, Zhang Dong, Arafa Hossam M M, Hamada Farid M A, Fouad Hala, Walker Cheryl C, Al-Hendy Ayman

Abstract excerpt

OBJECTIVE: To evaluate the utility of gene therapy for uterine fibroids in the Eker rat model using an adenovirus-mediated delivery of a dominant-negative estrogen receptor gene (Ad-DNER). DESIGN: Animal study. SETTING: University animal laboratory. ANIMAL(S): Twenty-seven female Eker rats. INTERVENTION(S): We randomized Eker rats with magnetic resonance imaging (MRI)-confirmed uterine leiomyomas to a single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Humoral

Share to Leiomyoma

Share to Rats, Mutant Strains

Share to Tuberous Sclerosis Complex 2 Protein

Share to Tumor Burden

Share to Uterine Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 19144333
DOI: 10.1016/j.fertnstert.2008.09.086
PMCID: PMC2812608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model.PMID 19144333Read ↗

Gene therapy and uterine leiomyoma: a review.Semantic proximity Read ↗

Uterine leiomyoma in the Eker rat: A unique model for important diseases of womenSemantic proximity Read ↗

Role of hormonal and reproductive factors in the etiology and treatment of uterine leiomyoma.Semantic proximity Read ↗

Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma CellsSemantic proximity Read ↗

Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators.Semantic proximity Read ↗

Long-term efficacy of fibroid devascularization with ultrasound-guided high-intensity focused ultrasoundSemantic proximity Read ↗

The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers.Semantic proximity Read ↗

Elimusertib (BAY1895344), a novel ATR inhibitor, demonstrates in vivo activity in ATRX mutated models of uterine leiomyosarcoma.Semantic proximity Read ↗

504 Intratumoral delivery of Interleukin-12 DNA via in vivo electroporation leads to regression of injected and non-injected tumors in Merkel cell carcinoma: Final Results of a phase 2 studySemantic proximity Read ↗

Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor beta-3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.