Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model.

doi:10.1016/j.fertnstert.2008.09.086

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Article

Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model.

Fertility and sterility - 1 Jan 2010

Hassan Memy H, Salama Salama A, Zhang Dong, Arafa Hossam M M, Hamada Farid M A, Fouad Hala, Walker Cheryl C, Al-Hendy Ayman

Abstract excerpt

OBJECTIVE: To evaluate the utility of gene therapy for uterine fibroids in the Eker rat model using an adenovirus-mediated delivery of a dominant-negative estrogen receptor gene (Ad-DNER). DESIGN: Animal study. SETTING: University animal laboratory. ANIMAL(S): Twenty-seven female Eker rats. INTERVENTION(S): We randomized Eker rats with magnetic resonance imaging (MRI)-confirmed uterine leiomyomas to a single...

Topics

Adenoviridae
Animals
Apoptosis
Cell Cycle Proteins
Cell Proliferation
Disease Models, Animal
Estrogen Receptor alpha
Extracellular Matrix Proteins
Female
Gene Expression Regulation, Neoplastic
Genetic Therapy
Genetic Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Humoral

Leiomyoma

Magnetic Resonance Imaging

Mutation

Rats

Rats, Mutant Strains

Source

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Identifiers

PMID: 19144333
DOI: 10.1016/j.fertnstert.2008.09.086
PMCID: PMC2812608

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