Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans.

doi:10.1099/00221287-142-4-937

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Article

Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans.

Microbiology (Reading, England) - 1 Apr 1996

Chaturvedi Vishnu, Flynn Timothy, Niehaus Walter G, Wong Brian

Abstract excerpt

Cryptococcus neoformans produces large amounts of the acyclic hexitol mannitol in culture and infected animals, but the functional and pathogenic significance of mannitol production by this fungus is not known. We exposed C. neoformans H99 (Cn H99) to UV irradiation (1 x LD50) and screened surviv...

Topics

Animals
Cryptococcosis
Cryptococcus neoformans
Hot Temperature
Male
Mannitol
Mice
Mutation
Osmotic Pressure
Stress, Physiological
Virulence

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