Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.

doi:10.1242/jcs.109.3.579

Back to search

Article

Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.

Journal of cell science - 1 Mar 1996

Gao F B, Keene J D

Abstract excerpt

Human proteins Hel-N1 and Hel-N2 contain three RNA recognition motifs (RRMs), and are members of a family of proteins highly homologous to Drosophila ELAV, which is essential for neuronal differentiation. Both proteins bind to A+U-rich 3' untranslated regions of a variety of growth-related mRNAs...

Topics

Animals
Base Sequence
Carcinoma, Embryonal
Cell Differentiation
Cytosol
Humans
Molecular Sequence Data
Nerve Tissue Proteins
Neurons
Phenotype
Protein Biosynthesis
RNA, Messenger
Rats
Ribonucleoproteins
Tumor Cells, Cultured
Up-Regulation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.