Article
Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely related DQB1*0602 allele via sequence specific PCR or direct DNA sequencing.
Tissue antigens - 1 Sept 1996
Williams T M, Bassinger S, Moehlenkamp C, Wu J, Montoya G D, Griffith B B, McAuley J D, Goldman S, Maurer D H, Troup G M
Abstract excerpt
A novel DQ6 allele (DQB1*0611) was identified via direct DNA sequencing in an African-American donor for bone marrow transplantation. The allele was not suspected on the basis of a sequence specific PCR assay which instead indicated the presence of DQB1*0602. DQB1*0602 and DQB1*0611 differ in exo...
Topics
- Alleles
- Base Sequence
- Diagnosis, Differential
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational