PCR analysis of polymorphisms at the D13S25 locus.

Abstract excerpt

Evidence that the D13S25 locus lies close to a potential tumour suppressor gene implicated in the pathogenesis of B-CLL has been based on detection of LOH and bi-allelic loss using the pH2-42 probe. The SspI polymorphism detected by this probe has been identified by sequencing adjacent clones and a polymorphic (TA)n repeat has been found. Amplification of the region encompassing both polymorphic markers by PCR...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Biomarkers, Tumor
• Share to Chromosomes, Human, Pair 13