A mutant (Arg327-->His) GPIIb associated to thrombasthenia exerts a dominant negative effect in stably transfected CHO cells.

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Article

A mutant (Arg327-->His) GPIIb associated to thrombasthenia exerts a dominant negative effect in stably transfected CHO cells.

Thrombosis and haemostasis - 1 Sept 1996

Ferrer M, Fernández-Pinel M, González-Manchón C, González J, Ayuso M S, Parrilla R

Abstract excerpt

This work reports the structural and functional characterization of the platelet glycoprotein complex GPIIb-IIIa (integrin alpha IIb beta 3) in a patient of type II Glanzmann thrombasthenia, bearing a homozygous G-->A base transition at position 1074 of GPIIb that results in an Arg327-->His subst...

Topics

Adult
Animals
Arginine
CHO Cells
Cricetinae
Gene Expression Regulation
Genes, Dominant
Humans
Male
Mutation
Platelet Glycoprotein GPIIb-IIIa Complex
Thrombasthenia
Transfection

Source

Open in PubMed

Identifiers

PMID: 8883261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8883261-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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