Article
Purkinje cell loss and astrocytosis in the cerebellum in familial and sporadic Alzheimer's disease.
Neuroscience letters - 16 Aug 1996
Fukutani Y, Cairns N J, Rossor M N, Lantos P L
Abstract excerpt
In order to elucidate further the pathological differences between familial Alzheimer's disease (FAD) and sporadic Alzheimer's disease (SAD), Purkinje cells and astrocytosis in the cerebellum of 10 FAD patients including two cases with the beta-amyloid precursor protein (APP) gene mutation in codon 717 (APP717 Val-->Ile), 10 SAD patients and 10 non-demented, age-matched controls were morphometrically investigated...
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