Founder effect in spinal and bulbar muscular atrophy (SBMA).

doi:10.1093/hmg/5.9.1253

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Article

Founder effect in spinal and bulbar muscular atrophy (SBMA).

Human molecular genetics - 1 Sept 1996

Tanaka F, Doyu M, Ito Y, Matsumoto M, Mitsuma T, Abe K, Aoki M, Itoyama Y, Fischbeck K H, Sobue G

Abstract excerpt

We analyzed the polymorphic (CAG)n and (GGC)n repeats of the androgen receptor gene in 113 unrelated X-linked spinal and bulbar muscular atrophy (SBMA) X chromosomes and 173 control X chromosomes in Japanese males. The control chromosomes had an average CAG repeat number of 21 +/- 3 with a range...

Topics

Genetic Linkage
Humans
Motor Neuron Disease
Muscular Atrophy
Mutation
Receptors, Androgen
Repetitive Sequences, Nucleic Acid

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