Article
The hypercube structure of the genetic code explains conservative and non-conservative aminoacid substitutions in vivo and in vitro.
Bio Systems - 1 Jan 1996
Jiménez-Montaño M A, de la Mora-Basánez C R, Pöschel T
Abstract excerpt
A representation of the genetic code as a six-dimensional Boolean hypercube is described. This structure is the result of the hierarchical order of the interaction energies of the bases in codon-anticodon recognition. In this paper it is applied to study molecular evolution in vivo and in vitro. In the first case we compared aligned positions in homologous protein sequences and found two different behaviors: (a)...
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