Article
The influence of class II HLA type on the lymphoproliferative response of normal donors to a bcr-abl fusion peptide.
Experimental hematology - 1 Sept 1996
MacIntyre A R, Christmas S E, Clark R E
Abstract excerpt
Chronic myelogenous leukemia (CML) is characterized by a t(9;22) chromosomal translocation resulting in the expression of a novel bcr-abl fusion protein. The region spanning the fusion point is novel to the immune system and hence represents a potential leukemia-specific antigen. The ability of a 21-mer b3a2 fusion peptide to induce an in vitro lymphoproliferative response in a panel of 54 normal donors has been...
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