Article
Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses.
Human mutation - 1 Jan 1996
De Vries E M, Ricke D O, De Vries T N, Hartmann A, Blaszyk H, Liao D, Soussi T, Kovach J S, Sommer S S
Abstract excerpt
Germline and somatic mutations in the p53 and APC genes contribute to neoplasia. The patterns of these and other acquired mutations in cancers reflect environmental mutagens and endogenous factors that contribute to carcinogenesis. Herein, we describe a database of almost 2,300 mutations in the p...
Topics
- Computer Communication Networks
- Databases, Factual
- Genes, APC
- Genes, p53
- Germ-Line Mutation
- Humans
- Molecular Epidemiology
- Mutation
- Neoplasms
- Polymorphism, Genetic