Article
Clinical features and natural history of spinocerebellar ataxia type 1.
Acta neurologica Scandinavica - 1 Jan 1996
Sasaki H, Fukazawa T, Yanagihara T, Hamada T, Shima K, Matsumoto A, Hashimoto K, Ito N, Wakisaka A, Tashiro K
Abstract excerpt
SCA1 is a dominant spinocerebellar ataxia (SCA) and a multi-systemic syndrome caused by abnormal expansion of unstable CAG repeat in a novel gene located on chromosome 6p22-p23. We clinically studied 35 Japanese SCA1 patients who were assumed to have come from a common origin. The age at onset ranged from 15-63 years, and significantly correlated with CAG repeat units of mutant alleles. Ataxia was the initial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.