Article
Functional and structural role of arginine 103 in human erythropoietin.
Archives of biochemistry and biophysics - 15 Sept 1996
Grodberg J, Davis K L, Sytkowski A J
Abstract excerpt
The identification of amino acid residues essential for function of the hematopoietic growth factor erythropoietin has been approached by several methods, including comparisons of related sequences, immunochemical approaches, mutagenesis, and computer modeling. We have reported previously that mutations within amino acids 100-109 of erythropoietin can have profound effects on the hormone's structure and/or...
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