Article
Validation of the determination of deltaF508 mutations of the cystic fibrosis gene in over 11 000 mouthwashes.
Human genetics - 1 Mar 1996
de Vries H G, Collèe J M, van Veldhuizen M H, Achterhof L, Smit Sibinga C T, Scheffer H, Buys C H, ten Kate L P
Abstract excerpt
Mouthwashes can be used as a DNA resource for mutation detection and, because collection and DNA isolation is simple and cheap, they could in particular, be used for large numbers of samples. To determine the failure rate (the proportion of mouth samples in which no PCR product was obtained) and the specificity of buccal epithelial cell mutation detection in large numbers of samples, we collected mouthwashes and...
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