HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.

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Article

HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.

Oncogene - 1 Aug 1996

Thomas M, Massimi P, Banks L

Abstract excerpt

The E6 proteins of the oncogenic-associated human papillomavirus types 16 (HPV-16) and 18 (HPV-18) function by interfering with the normal cell cycle control mechanisms, particularly those controlled by p53. HPV E6 is able to interfere with p53 function by preventing its binding to DNA target seq...

Topics

Animals
Base Sequence
Binding Sites
DNA
DNA-Binding Proteins
Humans
Mice
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral
Promoter Regions, Genetic
Structure-Activity Relationship
TATA-Box Binding Protein
Transcription Factors
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8760288

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8760288-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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