Article
C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 1996
Griffith M E, Lovegrove J U, Gaskin G, Whitehouse D B, Pusey C D
Abstract excerpt
BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) in vasculitis have either cANCA or pANCA patterns as defined by immunofluorescence. The target autoantigen of cANCA is usually proteinase 3 (PR3), whereas that of pANCA is usually myeloperoxidase (MPO). Alpha-1-antitrypsin (alpha 1AT) is th...
Topics
- Alleles
- Antibodies, Antineutrophil Cytoplasmic
- Autoantibodies
- Autoantigens
- DNA
- Enzyme-Linked Immunosorbent Assay
- Fluorescent Antibody Technique, Indirect
- Humans
- Isoelectric Focusing
- Myeloblastin
- Peroxidase
- Phenotype
- Serine Endopeptidases