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Article

Identification of domains in human beta-hexosaminidase that determine substrate specificity.

The Journal of biological chemistry - 19 Jul 1996

Pennybacker M, Liessem B, Moczall H, Tifft C J, Sandhoff K, Proia R L

Abstract excerpt

The lysosomal beta-hexosaminidases are dimers composed of alpha and beta subunits. beta-Hexosaminidase A (alphabeta) is a heterodimer, whereas hexosaminidase B (betabeta) and S (alphaalpha) are homodimers. Although containing a high degree of amino acid identity, each subunit expresses a unique active site that can be distinguished by a differential ability to hydrolyze charged substrates. The site on the...

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Identifiers

PMID: 8663217
DOI: 10.1074/jbc.271.29.17377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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