Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells.

Article

Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells.

Journal of lipid research - 1 Nov 1995

Krapp A, Zhang H, Ginzinger D, Liu M S, Lindberg A, Olivecrona G, Hayden M R, Beisiegel U

Abstract excerpt

Lipoprotein lipase (LpL) has been shown to mediate the uptake of lipoproteins into cells. The uptake is initiated by binding of LpL to cell surface proteoglycans and to the low density lipoprotein (LDL) receptor-related protein. This ability of LpL is independent of catalytic activity and depends...

Topics

Catalysis
Cell Line
Cells
Heparin
Humans
Lipoprotein Lipase
Lipoproteins
Mutation
Protein Binding
Structure-Activity Relationship
Tumor Cells, Cultured

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