[Analysis of trinucleotide repeat expansion as a new mechanism of mutation in Huntington's chorea: theoretical and applied aspects].

Article

[Analysis of trinucleotide repeat expansion as a new mechanism of mutation in Huntington's chorea: theoretical and applied aspects].

Genetika - 1 Jan 1996

Illarioshkin S N, Ivanova-Smolenskaia I A, Markova E D, Nikol'skaia N N, Chabrashvili T Z, Insarova N G

Abstract excerpt

The Huntington's chorea mutation consists of expansion of trinucleotide CAG repeats in the recently discovered gene IT-15. In this work, for the first time in a population of Russian patients, correlations between the number of copies of CAG repeats and various clinical characteristics of the dis...

Topics

Age of Onset
Alleles
Ethnicity
Female
Humans
Huntington Disease
Male
Mutation
Oligonucleotides
Prognosis
Risk Factors
Russia
Trinucleotide Repeats

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