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Article

Non-disjunction in human sperm: evidence for an effect of increasing paternal age

1 Jan 1995

Abstract excerpt

In humans, the relationship between advancing maternal age and the incidence of trisomy has been long established, but the possible effect of increasing age of the father remains controversial. Using a fluorescence in situ hybridization (FISH) approach to directly examine individual sperm for aneuploidy of the sex chromosomes and chromosome 18, we have analyzed approximately 400,000 sperm from 24 men aged 18-60...

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Share to Demographic Trends and Gender Preferences
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Share to Prenatal Screening and Diagnostics

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PMID: 8634691
DOI: 10.1093/hmg/4.12.2227

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