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Meiotic Nondisjunction of Chromosomes 1, 17, 18, X, and Y in Men More Than 80 Years of Age

1 Dec 2000

Abstract excerpt

In order to evaluate a possible paternal age effect, testicular sperm cells from three men aged 81, 82, and 83 yr were analyzed by two-color- and three-color-fluorescence in situ hybridization for disomy rates of chromosomes 1, 17, 18, X, and Y as well as for diploidy frequencies. A minimum of 1500 sperm cells per donor and probe was evaluated due to the low number of spermatozoa in the preparations. Diploidy and...

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Share to Chromosomal and Genetic Variations
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PMID: 11090442
DOI: 10.1095/biolreprod63.6.1727

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