Article
On signal sequence polymorphisms and diseases of distribution.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 1996
Rosenblum J S, Gilula N B, Lerner R A
Abstract excerpt
We report a previously unappreciated property of the signals that target organelle-specific proteins to their subcellular sites of action. Such targeting sequences are shown to be polymorphic. We discovered this polymorphism when we cloned the mitochondrial manganese-containing superoxide dismuta...
Topics
- Base Sequence
- Cell Line
- Cloning, Molecular
- Cockayne Syndrome
- DNA Primers
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Progeria
- Protein Sorting Signals
- Superoxide Dismutase
- Werner Syndrome