Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.

doi:10.1212/wnl.46.2.406

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Article

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.

Neurology - 1 Feb 1996

Lippa C F, Saunders A M, Smith T W, Swearer J M, Drachman D A, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson M D, Farlow M, Hyman B T, George-Hyslop S P, Roses A D, Pollen D A

Abstract excerpt

Whether all etiologic forms of Alzheimer's disease (AD) share a final common pathway is a major issue. We determined the severity and regional distribution of neuronal loss, amyloid plaques, neuritic plaques (NPs), and neurofibrillary tangles (NFTs), and calculated the ratio of neuronal loss to N...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Amyloid
Amyloid beta-Protein Precursor
Analysis of Variance
Apolipoproteins E
Brain
Cerebellum
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 21
Gene Frequency
Genetic Linkage

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Humans

Middle Aged

Mutation

Neurites

Source

Open in PubMed

Identifiers

PMID: 8614503
DOI: 10.1212/wnl.46.2.406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8614503-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.