Article
Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.
Neurology - 1 Feb 1996
Lippa C F, Saunders A M, Smith T W, Swearer J M, Drachman D A, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson M D, Farlow M, Hyman B T, George-Hyslop S P, Roses A D, Pollen D A
Abstract excerpt
Whether all etiologic forms of Alzheimer's disease (AD) share a final common pathway is a major issue. We determined the severity and regional distribution of neuronal loss, amyloid plaques, neuritic plaques (NPs), and neurofibrillary tangles (NFTs), and calculated the ratio of neuronal loss to NPs and NFTs in brains of 19 familial AD (FAD) patients with linkage to chromosome 14, six AD patients with mutations of...
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