Article
High adhesiveness of encapsulated Neisseria meningitidis to epithelial cells is associated with the formation of bundles of pili.
Molecular microbiology - 1 Sept 1995
Marceau M, Beretti J L, Nassif X
Abstract excerpt
Pili are indispensable in adhesion of encapsulated Neisseria meningitidis (MC) to eukaryotic cells. Intrastrain variability with respect to the degree of adhesion is the result of pilin antigenic variation. We have localized the region responsible for this variability to the 20-amino-acid hypervariable domain of pilin. The replacement of an aspartic acid, located in the hypervariable region of a low-adhesive...
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