Article
[Induction of antibiotic formation by inactive cultures of actinomycetes. A mutant strain of Streptomyces helvaticus, a new producer of bruneomycin].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Jun 1995
Malkina N D, Dudnik Iu V, Lysenkova L N, Terekhova L P, Katrukha G S
Abstract excerpt
After exposure of an inactive actinomycete to ethidium bromide a stable mutant producing an antibiotic on a solid medium was isolated. The exposure to methylnitrosoguanidine provided the isolation of a more productive variant synthesizing the antibiotic in a liquid medium. By UV, IR, NMR and mass spectroscopy the antibiotic was identified as bruneomycin (streptonigrin). The taxonomic investigation of the culture...
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