Article
Exposure of Escherichia coli to acid habituation conditions sensitizes it to alkaline stress.
Letters in applied microbiology - 1 Jan 1996
Rowbury R J, Hussain N H
Abstract excerpt
Escherichia coli transferred from pHo 7.0 to pHo 5.5 or 6.0 became alkali-sensitive by a rapidly induced phenotypic response. Alkali sensitization was reduced at pHo 5.0 and virtually abolished at pHo 6.5. The response was triggered by cytoplasmic rather than external or periplasmic acidification and de novo protein synthesis was needed. Alkali sensitivity failed to appear at pHo 5.5 plus DNA gyrase inhibitors...
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