Article
Phenotypic variability in van der Woude syndrome.
Genetic counseling (Geneva, Switzerland) - 1 Jan 1995
Lacombe D, Pedespan J M, Fontan D, Chateil J F, Verloes A
Abstract excerpt
The association of lower lip pits with cleft lip and/or palate defines the van der Woude syndrome (VWS). VWS has an autosomal dominant mode of inheritance wiht a high penetrance and a variable expression. A gene involved in the origin of VWS is linked to loci on chromosome 1q32-q41. The gene might be involved in the programmed cell death of neural crest derived cells. Other malformations have been associated with...
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