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Article

Analysis of the Bruton's tyrosine kinase gene promoter reveals critical PU.1 and SP1 sites

1 Feb 1996

Abstract excerpt

The gene defective in X-linked agammaglobulinemia (XLA) encodes a novel protein kinase termed Bruton's tyrosine kinase (Btk). Whereas the XLA phenotype is confined to abnormalities of B-cell development and function, Btk is expressed not only in B-lymphocyte lineage but also in myeloid lineage cells. The first 450 basepairs of the Btk promoter fused to a luciferase gene displayed a similar cell-type specificity....

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Identifiers

PMID: 8562928
DOI: 10.1182/blood.v87.3.1036.bloodjournal8731036

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Analysis of the Bruton's tyrosine kinase gene promoter reveals critical PU.1 and SP1 sitesPMID 8562928Read ↗

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